Crop Science Centre

Driven by impact, fuelled by excellence

Dr Sebastian Eves-van den Akker

Dr Sebastian Eves-van den Akker

Head of Plant-Parasite Interactions Group
Plant-parasitic interactions

Biography

Sebastian received his Ph. D. in plant pathology from the University of Leeds and the James Hutton Institute in 2014. Sebastian was then awarded an Anniversary Future Leaders Fellowship from the Biotechnology and Biological Sciences Research Council to pursue independent research at the University of Dundee and the John Innes Centre (2015-2018). In 2018, he was awarded a BBSRC David Phillips Fellowship and established the Plant-Parasite Interactions group at the Department of Plant Sciences, University of Cambridge.

Publications

Genome Expression Dynamics Reveal the Parasitism Regulatory Landscape of the Root-Knot Nematode Meloidogyne incognita and a Promoter Motif Associated with Effector Genes.

Da Rocha M, Bournaud C, Dazenière J, Thorpe P, Bailly-Bechet M, Pellegrin C, Péré A, Grynberg P, Perfus-Barbeoch L, Eves-van den Akker S, Danchin EGJ.Genes (Basel). 2021 May 18;12(5):771. doi: 10.3390/genes12050771.PMID: 34070210 Free PMC article.

Recent applications of biotechnological approaches to elucidate the biology of plant-nematode interactions.

Eves-van den Akker S, Stojilković B, Gheysen G.Curr Opin Biotechnol. 2021 Aug;70:122-130. doi: 10.1016/j.copbio.2021.03.008. Epub 2021 Apr 28.PMID: 33932862 Review.

Plant-nematode interactions.

Eves-van den Akker S.Curr Opin Plant Biol. 2021 Mar 27;62:102035. doi: 10.1016/j.pbi.2021.102035. Online ahead of print.PMID: 33784578 Review.

Toward genetic modification of plant-parasitic nematodes: delivery of macromolecules to adults and expression of exogenous mRNA in second stage juveniles.

Kranse O, Beasley H, Adams S, Pires-daSilva A, Bell C, Lilley CJ, Urwin PE, Bird D, Miska E, Smant G, Gheysen G, Jones J, Viney M, Abad P, Maier TR, Baum TJ, Siddique S, Williamson V, Akay A, Eves-van den Akker S.G3 (Bethesda). 2021 Feb 9;11(2):jkaa058. doi: 10.1093/g3journal/jkaa058.PMID: 33585878 Free PMC article.

How Do Pathogens Evolve Novel Virulence Activities?

Sacristán S, Goss EM, Eves-van den Akker S.Mol Plant Microbe Interact. 2021 Jul 23:MPMI09200258IA. doi: 10.1094/MPMI-09-20-0258-IA. Online ahead of print.PMID: 33522842 Free article.

A new esophageal gland transcriptome reveals signatures of large scale de novo effector birth in the root lesion nematode Pratylenchus penetrans.

Vieira P, Shao J, Vijayapalani P, Maier TR, Pellegrin C, Eves-van den Akker S, Baum TJ, Nemchinov LG.BMC Genomics. 2020 Oct 23;21(1):738. doi: 10.1186/s12864-020-07146-0.PMID: 33096989 Free PMC article.

Signatures of adaptation to a monocot host in the plant-parasitic cyst nematode Heterodera sacchari.

Pokhare SS, Thorpe P, Hedley P, Morris J, Habash SS, Elashry A, Eves-van den Akker S, Grundler FMW, Jones JT.Plant J. 2020 Aug;103(4):1263-1274. doi: 10.1111/tpj.14910. Epub 2020 Jul 22.PMID: 32623778

The draft genome of Ditylenchus dipsaci.

Mimee B, Lord E, Véronneau PY, Masonbrink R, Yu Q, Akker SED.J Nematol. 2019;51:1-3. doi: 10.21307/jofnem-2019-027.PMID: 31132003 Free PMC article.

A genomic resource for the sedentary semi-endoparasitic reniform nematode, Rotylenchulus reniformis Linford & Oliveira.

Showmaker KC, Sanders WS, Eves-van den Akker S, Martin BE, Platt RN 2nd, Stokes JV, Hsu CY, Bartlett BD, Peterson DG, Wubben MJ.J Nematol. 2019;51:1-2. doi: 10.21307/jofnem-2019-013.PMID: 31088025 Free PMC article.

The genome of the soybean cyst nematode (Heterodera glycines) reveals complex patterns of duplications involved in the evolution of parasitism genes.

Masonbrink R, Maier TR, Muppirala U, Seetharam AS, Lord E, Juvale PS, Schmutz J, Johnson NT, Korkin D, Mitchum MG, Mimee B, den Akker SE, Hudson M, Severin AJ, Baum TJ.BMC Genomics. 2019 Feb 7;20(1):119. doi: 10.1186/s12864-019-5485-8.PMID: 30732586 Free PMC article.

Publications

Targeted transcriptomics reveals signatures of large-scale independent origins and concerted regulation of effector genes in Radopholus similis
Paulo Vieira, Roxana Y Myers, Clement Pellegrin, Catherine Wram, Cedar Hesse, Thomas R Maier, Jonathan Shao, Georgios D Koutsovoulos, Inga Zasada, Tracie Matsumoto, Etienne G J Danchin, Thomas J Baum, Sebastian Eves-van den Akker, Lev G Nemchinov PLoS pathogens 2021-11-08 pmid:34748609 pmc:PMC8601627 doi:10.1371/journal.ppat.1010036

Genome Expression Dynamics Reveal the Parasitism Regulatory Landscape of the Root-Knot Nematode Meloidogyne incognita and a Promoter Motif Associated with Effector Genes
Martine Da Rocha, Caroline Bournaud, Julie Dazenière, Peter Thorpe, Marc Bailly-Bechet, Clément Pellegrin, Arthur Péré, Priscila Grynberg, Laetitia Perfus-Barbeoch, Sebastian Eves-van den Akker, Etienne G J Danchin Genes 2021-06-02 pmid:34070210 pmc:PMC8158474 doi:10.3390/genes12050771

Recent applications of biotechnological approaches to elucidate the biology of plant-nematode interactions
Sebastian Eves-van den Akker, Boris Stojilković, Godelieve Gheysen Current opinion in biotechnology 2021-05-01 pmid:33932862 doi:10.1016/j.copbio.2021.03.008

Plant-nematode interactions
Sebastian Eves-van den Akker Current opinion in plant biology 2021-03-30 pmid:33784578 doi:10.1016/j.pbi.2021.102035

Toward genetic modification of plant-parasitic nematodes: delivery of macromolecules to adults and expression of exogenous mRNA in second stage juveniles
Olaf Kranse, Helen Beasley, Sally Adams, Andre Pires-daSilva, Christopher Bell, Catherine J Lilley, Peter E Urwin, David Bird, Eric Miska, Geert Smant, Godelieve Gheysen, John Jones, Mark Viney, Pierre Abad, Thomas R Maier, Thomas J Baum, Shahid Siddique, Valerie Williamson, Alper Akay, Sebastian Eves-van den Akker G3 (Bethesda, Md.) 2021-02-15 pmid:33585878 pmc:PMC8022973 doi:10.1093/g3journal/jkaa058

How Do Pathogens Evolve Novel Virulence Activities?
Soledad Sacristán, Erica M Goss, Sebastian Eves-van den Akker Molecular plant-microbe interactions : MPMI 2021-02-01 pmid:33522842 doi:10.1094/MPMI-09-20-0258-IA

A new esophageal gland transcriptome reveals signatures of large scale de novo effector birth in the root lesion nematode Pratylenchus penetrans
Paulo Vieira, Jonathan Shao, Paramasivan Vijayapalani, Thomas R Maier, Clement Pellegrin, Sebastian Eves-van den Akker, Thomas J Baum, Lev G Nemchinov BMC genomics 2020-10-24 pmid:33096989 pmc:PMC7585316 doi:10.1186/s12864-020-07146-0

Signatures of adaptation to a monocot host in the plant-parasitic cyst nematode Heterodera sacchari
Somnath S Pokhare, Peter Thorpe, Pete Hedley, Jennifer Morris, Samer S Habash, Abdelnaser Elashry, Sebastian Eves-van den Akker, Florian M W Grundler, John T Jones The Plant journal : for cell and molecular biology 2020-07-06 pmid:32623778 doi:10.1111/tpj.14910

The draft genome of Ditylenchus dipsaci
Benjamin Mimee, Etienne Lord, Pierre-Yves Véronneau, Rick Masonbrink, Qing Yu, Sebastian Eves-van den Akker Journal of nematology 2019-05-28 pmid:31132003 pmc:PMC6929663 doi:10.21307/jofnem-2019-027

A genomic resource for the sedentary semi-endoparasitic reniform nematode, Rotylenchulus reniformis Linford & Oliveira
Kurt C Showmaker, William S Sanders, Sebastian Eves-van den Akker, Brigitte E Martin, Roy N Platt, John V Stokes, Chuan-Yu Hsu, Benjamin D Bartlett, Daniel G Peterson, Martin J Wubben Journal of nematology 2019-05-16 pmid:31088025 pmc:PMC6929637 doi:10.21307/jofnem-2019-013

The genome of the soybean cyst nematode (Heterodera glycines) reveals complex patterns of duplications involved in the evolution of parasitism genes
Rick Masonbrink, Tom R Maier, Usha Muppirala, Arun S Seetharam, Etienne Lord, Parijat S Juvale, Jeremy Schmutz, Nathan T Johnson, Dmitry Korkin, Melissa G Mitchum, Benjamin Mimee, Sebastian Eves-van den Akker, Matthew Hudson, Andrew J Severin, Thomas J Baum BMC genomics 2019-02-09 pmid:30732586 pmc:PMC6367775 doi:10.1186/s12864-019-5485-8

Shared Transcriptional Control and Disparate Gain and Loss of Aphid Parasitism Genes
Peter Thorpe, Carmen M Escudero-Martinez, Peter J A Cock, Sebastian Eves-van den Akker, Jorunn I B Bos Genome biology and evolution 2018-08-31 pmid:30165560 pmc:PMC6186164 doi:10.1093/gbe/evy183

Correction to: STATAWAARS: a promoter motif associated with spatial expression in the major effector-producing tissues of the plantparasitic nematode Bursaphelenchus xylophilus
Margarida Espada, Sebastian Eves-van den Akker, Tom Maier, Paramasivan Vijayapalani, Thomas Baum, Manuel Mota, John T Jones BMC genomics 2018-08-12 pmid:30097016 pmc:PMC6085758 doi:10.1186/s12864-018-4990-5

STATAWAARS: a promoter motif associated with spatial expression in the major effector-producing tissues of the plant-parasitic nematode Bursaphelenchus xylophilus
Margarida Espada, Sebastian Eves-van den Akker, Tom Maier, Paramasivan Vijayapalani, Thomas Baum, Manuel Mota, John T Jones BMC genomics 2018-07-29 pmid:30053797 pmc:PMC6062891 doi:10.1186/s12864-018-4908-2

Duplication of hsp-110 Is Implicated in Differential Success of Globodera Species under Climate Change
Laura M Jones, Sebastian Eves-van den Akker, Patricija van-Oosten Hawle, Howard J Atkinson, Peter E Urwin Molecular biology and evolution 2018-06-30 pmid:29955862 pmc:PMC6188557 doi:10.1093/molbev/msy132